Read e-book online A Computer Scientist's Guide to Cell Biology PDF

By William W. Cohen

ISBN-10: 038748275X

ISBN-13: 9780387482750

This publication is designed particularly as a advisor for machine Scientists wanting an creation to telephone Biology. The textual content explores 3 diverse features of biology: organic platforms, experimental tools, and language and nomenclature. the writer discusses what biologists are attempting to figure out from their experiments, how quite a few experimental approaches are used and the way they relate to approved techniques in machine technology, and the vocabulary essential to learn and comprehend present literature in biology. The e-book is a useful reference instrument and a very good start line for a extra complete exam of phone biology.

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However, gene chips can be manufactured repeatedly at moderate cost, and hence the effort of designing and 54 A Computer Scientist’s Guide to Cell Biology engineering them—the vast bulk of the total cost—can be amortized (“reused,” if you like) over many related experiments. This is an important development, as doing a Western blot (or similar biological experimental procedures) requires technical expertise, practice, and some natural dexterity to accomplish successfully. This sort of human skill cannot be duplicated without expensive and painful processes (like postsecondary education).

One great advantage of these techniques, which I have not emphasized so far, is that it is often easy to apply them in parallel, to many mixtures at once. As a computer scientist, I have been struck by the widespread use of this sort of “parallel processing” in biological experimentation. In particular, all of the “blot-like” methods discussed above—Northern, Southern, and Western blots, microarrays, and gene and proteome chips—are naturally parallel. Consider a Western blot, which tests a protein X for interactions with the proteins on a blot: the experiment remains the same, whether the blot contains 100 proteins, 1000 proteins, or 10,000 proteins.

The next steps in the cycle will convert the succinyl-CoA to succinate and then fumarate, producing two more high-energy molecules, GTP and E-FADH2. Figure 17. Part of an energy-producing pathway. ) is different, each enzyme is also different: thus a pathway that either consumes or produces large amounts of energy will often involve many different enzymes, again contributing to complexity. William W. Cohen 31 Amplification and pathways Sometimes a pathway will act to ampli- The “fuel” used in a cell is fy a weak initial signal.

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A Computer Scientist's Guide to Cell Biology by William W. Cohen


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